CHIP (Clonal Hematopoiesis of Indeterminate Potential)
نویسندگان
چکیده
منابع مشابه
Copy number alterations detected as clonal hematopoiesis of indeterminate potential.
Recent studies have revealed that clonal hematopoiesis of indeterminate potential (CHIP) is an important risk factor for therapy-related myeloid neoplasms (t-MNs). CHIP is currently defined as a clonal hematopoietic population carrying somatic point mutations in 1 of the leukemia-associated genes. Patients with t-MNs often present with chromosomal abnormalities in addition to somatic point muta...
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Department of Medical Oncology, Division of Hematological Malignancies, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Boston, MA; Division of Hematology-Oncology, Moores Cancer Center at the University of California at San Diego, La Jolla, CA; Division of Hematology, Department of Medicine, Brigham and Women’s Hospital, Boston, MA; Department of Hematologic Oncology and Blood D...
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ژورنال
عنوان ژورنال: Circulation
سال: 2018
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.118.034392